CHAOULOFF Francis

Researcher (INSERM) at the Neurocentre Magendie (Bordeaux, FRANCE)

Short Biography

Francis Chaouloff graduated in 1985 while working on the neuropharmacology of the central serotoninergic systems. 

During his post-doc at Geneva, he was worked on the impact of serotoninergic systems on the metabolism. In 1988, he was recruited as a director of research at the French national health and medical research institute in Paris. He focused on serotoninergic systems and their impact on stress and physical activity. 

In 2007, he joins Giovanni Marsicano’s team at Bordeaux and starts working on the role of endocannabinoid systems on the adaptation to stress.

Research interests

Dr Marsicano’s team is interested in understanding the neurobiological bases of adaptation to stressful stimuli. The team is also interested in the role of endocannabinoid systems in anxiety and fear, the neurobehavioral impact on the hypothalamo-pituitary-adrenergic axis and to mechanisms of action of psychotropes.

Sources: inb.u-bordeaux2.fr et cvscience.aviesan.fr

Key Words

anxiety, endocannabinoids, depression, fear, stress, neuropsychopharmacology, psychotropes

Most relevant scientific publications

• Dostes S, Dubreucq S, Ladevèze E, Marsicano G, Abrous DN, Chaouloff F, Koehl M. Running per se stimulates the dendritic arbor of newborn dentate granule cells in mouse hippocampus in a duration-dependent manner. Hippocampus. 2015 Nov 25. 2015
• Belluomo I, Matias I, Pernègre C, Marsicano G, Chaouloff F. Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes. J Neurochem. 2015 Jan 27. 2015
• Dubreucq  S, Durand A, Matias I, Bénard G, Richard E, Soria-Gomez E, Glangetas C, Groc L, Wadleigh A, Massa F, Bartsch D, Marsicano G, Georges F, Chaouloff F. Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance. Biol. Psychiatry 2013; 73(9):895-903.
• Dubreucq S, Matias I, Cardinal P, Häring M, Lutz B, Marsicano G, Chaouloff F. Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. Neuropsychopharmacology 2012; 37(8):1885-1900.
• Hebert-Chatelain E, Reguero L, Puente N, Lutz B, Chaouloff F, Rossignol R, Piazza PV, Benard G, Grandes P, Marsicano G. Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor. Mol Metab. 2014 Apr 2;3(4):495-504.. 2014